not in use here
25 Katholieke Universiteit Leuven, BE
Role and Contribution
In the clinical trials the investigators will follow dendritic cell distribution/migration after daily repeated inguinal intranodal injections (two cycles of four injections 4-6 week apart) in patients with primary liver cancer, melanoma and renal cell carcinoma. The patients are pretreated with low dose cyclophosphamide and given IFN regimens. Dendritic cells in the clinical setting will be marked with 111-In and/or ferromagnetic SPIO to be monitored by scintigraphy and/or MRI. The group at CUN will also operate the PET equipment and synthetize the radioactive compounds used for PET imaging. This will chiefly include [18F]FHBG to trace HSV1-tk expressing DC in preclinical models.
Greetje Vande Velde
PhD. Greetje obtained her PhD in 2010 working in the laboratory of Prof. Veerle Baekelandt on the development of viral vectors for imaging reporter techniques. She holds a bachelor degree in medicine and a master degree in bioengineering (both K.U.Leuven). She has joined the Biomedical NMR Unit/Molecular Small Animal Imaging Center at K.U.Leuven in October 2009. Responsibility wihthin ENCITE: in vivo visualisation of cells and enzymes expressed by cells using multiple imaging techniques (MRI, optical etc.).